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Crosstalk between the redox signalling and the detoxification: GSTs under redox control

Notably, the pH responsiveness of CS further supports its microbiota-regulating effect: Its amino groups impart pH responsiveness, enabling environmentally triggered drug releaseit remains stable in the acidic gastric environment (pH 1.2) to avoid premature degradation, and only dissociates in the neutral-to-weakly alkaline colonic environment (pH 6.0-7.0) where it can directly interact with gut microbes and exert probiotic-enriching effects (187, 188)

however, they must be administered in smaller doses than intravenously

Magnesium in cardiovascular and other disorders